Millers in Marriage follows Eve Miller, the former lead singer-songwriter of an indie rock band, who finds herself drawn to a music journalist amid a toxic marriage. Meanwhile, Eve’s sister Maggie, a bestselling author, is encountering challenges in her marriage of 30 years as her career surpasses her husband’s. At the same time, Renee, a recently divorced successful fashion executive, is navigating a budding relationship with Andy Miller, an artist who is juggling his feelings for Renee and his recently separated wife Tina, Renee’s former colleague.